“Let a man be born at his own due time”
 
 
 
 

"All creatures have their determined time for giving birth and for carrying fetus, only a man is born all year long, not in determined time, one in the seventh month, the other in the eight, and so on till the beginning of the eleventh month."
Aristotle (384-322 B.C.)
Rudolf Klimek
 
 
 
 

Ob/Gyn Departments Jagiellonian University
Kopernika 23, 31-501Cracow, Poland
Phone number: 0048 12 421 36 66
 
 
 
 

The author points out the improper scales installed into all ultrasonographic devices what leads to neglecting the proper time of birth of nearly half of babies. Pregnancy ends with reaching full fetal maturity, which can and has to be quantized like e.g. radiation and thermal or electric conduction.Labor occurred at an improper time is a common obstetrical error, which finds confirmation among others in higher perinatal mortality indexes both at the beginning and the end of birth occurrence range in humans. Taking into account quantum mechanics and relativity of pregnancy duration one can - on the basis of two ultrasonographic measurements made within > 2 weeks - not only assess the current maturity, mass, length and gestational age of the unborn child but also predict those values in the perinatal period. Each obstetrician should permanently introduce two clinical criteria: distribution of birth in the range of six-week norm of occurrence in humans and ratio of premature infants to the mature ones at the gestational age <37 weeks counting from the last menstrual period. Key words: (3-6) Quantum mechanics, birth term, fetal maturity, ultrasonographic obstetrical scales.   Introduction

Quantum mechanics and theory of relativity are the most important scientific achievements of the twentieth century. Unfortunately, in spite of the great technological progress in the production of medical instruments and means of communication, they have not been used to the full in gynecological procedures. 100 years ago the notion of quantum and later timespace were introduced but obstetrician still adhere to out-of-date ideas of absolute time and space. As I. Newton in the seventeenth century they tend to put their trust in deterministic causality rather than their stochastic conditioning. To make matters worse, half of our colleagues - even if they know modern definitions of preterm and at term labor [23,24,29-31,40,41] – continue to assess fetal maturity according to fetal weight or calendar duration of pregnancy and on that premise they act improperly.

Pregnancy ends with reaching full fetal maturity, which can and has to be quantized like e.g. radiation and thermal or electric conduction. Likewise, mass is technically quantized in grams or kilograms, while gestational age is expressed in days, weeks or months. Maturity is neither mass nor time and cannot be assessed in grams or units of time. Therefore modern neonatologists and obstetricians successfully worked out maturity quantizing in points without taking into account mass, length or gestational age of fetuses and newborns [2,3,8,33-35,39]!

Science, Technology and Obstetrics

The fact that technologists install incorrect scales in ultrasonographic devices designed on the basis of the newest achievements of the twentieth century is reprehensible [5,7,25,27,28,30,36-38]. Everyone should be aware that on both sides of the mean value of the normal human pregnancy duration (281st-283rd day) there are two populations of newborns very much alike in their characteristics. Only 2.5% of these newborns have values of mass, length and maturity higher and lower than the range of the norm of the entire population, which pregnancies end within 6 weeks period. It was proven on hundreds of thousands and even millions (!) of observations of pregnancy duration in the whole world [1,4,10,42,44]! In the meantime, the scales of modern ultrasonographic devices do not cover the whole range of the 95% birth occurrence from 370/7 to 432/7 weeks after the last menstrual period. To make things worse, as the pregnancy progresses in weeks, the mean values of observed ultrasonographic measurements are falsely extrapolated or concealed by providing the wide range of standard duration +/- 3 weeks. These obvious arithmetic errors lead to iatrogenic and mediagenic diseases and deaths. Technicians not only use the falsely interpreted calendar scale of pregnancy durat ion playing up the role of the beginning of pregnancy at the expense of its much more important end. They entirely overlook the auxological laws, which are so well known from a later human developmental period i.e. sexual maturation. No one predicts the date of menarche on the basis of the absolute body mass or height but rather of the rate of their increase. Similarly, fetuses maturate slowly, regularly or fast, except that according to the auxological laws peers by the date conception but maturating faster have perinatal and target features smaller than the other children. Only newborns in 39th week have the distribution of their features closest to the normal. In fetuses which are born normally but earlier, the prevailing values are lower than the average, while in the most slowly maturating fetuses the situation is reverse.

One of the most frequent causes of instrumental deliveries, as well as the continuing 7-8% prematurity rate, is obstetricians ignorance of the achievements of auxology. Much better off are pediatricians, who observe auxological standards from the rate of birth of every human being. Every child up until the pubertal spurt generally develops in its own canal (range), whose change must be explained in every case. It is worthy of note that puberty is the next developmental stage following fetal maturation. Children which mature sooner have higher growth parameters than their peers, but the duration of their pubertal spurt is shorter and ultimately they grow to lower height. The same situation occurs before fetus reaches full maturity. The average values which determine weight and length of infants whose maturation is the fastest, i.e. those born in 37th week (37 0/7 - 37 6/7), are lower than in children born in 38th week, while it is only from 39th week that the characteristics of infants born in the following three labor weeks are stabilized. Only newborns in 39th week have the distribution of their features closest to the normal. In fetuses which are born normally but earlier, the prevailing values are lower than the average, while the most slowly maturing fetuses the situation is reverse (Figure 1).

Figure 1. Distribution of the neonatal features according to rate of fetal maturation

Thus, the auxological rules must not be disregarded. After all it suffices that in the proper period of pregnancy the obstetrician examines twice the development rate of fetal maturity. The data obtained from these examinations allow him to predict the birth-term with the accuracy of several days instead of weeks.

Real and statistical birth term

Everybody knows that he was born on a given day, while every obstetrician is able to prove that the commencing delivery and its prodromes occur during just two or three days of profound transformation from pregnancy to labor. Therefore the delivery date has to be estimated with accuracy of +/- 3 days. Unfortunately, to many obstetricians single out two days in the calendar pregnancy scale: the 259th day, starting from every fetus is magically considered “mature”, and then – somewhat contradictorily – the next day in question is 287th to 294th as the last one to determine maturity.

Extensive statistics show that from 287th day of the calendar scale to its 303rd day, there mature over ten percent of slowly developing fetuses. If the physician terminate these pregnancies by inducing labor, in at least several percent of cases he will deliver premature infants. If we consider 100 healthy women (100%) with the same beginning and normal course of pregnancy, 3 of them according to the Gauss curve will deliver in the first and 3 in the last week of the six-week range of the occurrence of births within 360/7 - 432/7 weeks after the last menstrual period, and 30 in each of the 2 middle weeks (390/7 - 406/7 ), while only 15 in 380/7 –386/7 and 410/7 –416/7 week. (Fig.2)

Figure 2. Normal occurence of human birth according to Gauss curve.

Pregnancy - just as every natural phenomenon (structure or process) - is an individual time spatial event whose most important element is fetal maturation of a human being, first to the level of viability, and then to full maturity to self-dependent life (Fig.3).

Figure 3 Fetal maturation to the level of viability and self-dependent life.

Out of the any group of 100 pregnant women with calendar age 370/7 - 376/7 weeks, only in 3 the process of fetal maturation is completed. Out of the remaining 97, only 15 will have it completed in 38th week and about twice as many in 39th week (Fig 4).

Figure 4 Full fetal maturity among 100 pregnant women at 370/7- 6/7 gestational week

When examine 50 pregnant women in 40th week, we have to realize that only approximately 30 out of their fetuses are mature for labor and other ones will deliver - unless pregnancy is iatrogenically terminated - after 287th day of physiologic pregnancy 410/7 week (Fig. 5).

Figure 5 Full fetal maturity among 51 pregnant women in 400/7 - 6/7 gestational week

After the 42nd week still 3% of children can be physiologically delivered. (Fig.6)

Figure 6 Comparison of pre-and postnatal ages of babies at 37th, 40th and 43rd weeks after LMP.

Conclusions

Modern medical means as ultrasonographic devices, cardiotocographs or neonatological incubators from the technical point of view stems from the greatest advances of quantum mechanics and theory of relativity. Unfortunately, their use in obstetrics paradoxically leads to iatrogenic morbidity and mortality due to lack of understanding of time-spatial fetal maturation and relativity of calendar pregnancy duration [6,11,14,22,26,30,32].

Labor occurred at an improper time is a common obstetrical error, which finds confirmation among others in higher perinatal mortality indexes both at the beginning (weeks 37th/38th) and the end (weeks 41st/42nd) of birth occurrence range in humans. The former is characterized by neglect of assistance in actual preterm labor one week before true individual term, and the latter by preterm labor induction or – even worse – attempts to bring belated assistance in postmature pregnancies, whose birth time has passed in the former weeks of the calendar scale of pregnancy duration.

By means of the presently used ultrasonographic devices but taking into account quantum mechanics and relativity of pregnancy duration one can - on the basis of two measurements made within 2 weeks - not only assess the current maturity, mass, length and gestational age of the unborn child but also predict those values in the perinatal period [13-22]. It brings measurable medical, social and financial profits and - most importantly – discards the ethics of reticence on the dangerous dominance of technology over general knowledge. It also reminds the doctors that their first obligation remains the tenet “primum non nocere”.

There was a time when improper use of cardiotocographs resulted in too much irreversible medical and social damage. The time has come to point one’s finger at manufacturers and users who bear the responsibility for similar effects in obstetrical ultrasonography. This is the best way to bring the percentage of prematurity down to the natural limit of 2.5% of all deliveries. Currently, 10-18% of labors are induced prematurely only because the calendar time of pregnancy duration has exceeded 287 or 294 days from the date of the last menstrual period, which additionally is given by the mothers accurate to several days, anyway.

The reduction of perinatal mortality – sometimes wrongly ascribed mainly to obstetricians – is primarily an effect of the amazing progress in neonatology. Low birth weight, perinatal mortality and prematurity rate have been even adopted as general social and economic indices of development of entire countries or at least selected territories. Therefore, to bring out the role of obstetricians there in, one should permanently introduce two other clinical criteria: distribution of birth in the range of six-week norm of occurrence in humans and ratio of premature infants to the mature ones at the gestational age <37 weeks counting from the last menstrual period.

References

  1. Alexander G.R. et al. A United States National Reference for fetal growth. Obstetrics and Gynecology (1996); 87:2: 163-168
  2. Amiel-Tison C, Maillatrd F, Lebrun F, Breart G, Papiernik E. Neurological and physical maturation in normal growth singletons from 37 to 41 weeks gestation. Early Hum Dev 1999;54:145-156.
  3. Ballard JL et al.New Ballard score expanded to include extremely premature infants. J Pediatr 1991;119:417-423.
  4. Bergsjø P et al.:Duration of human singleton pregancy. Acta Obstet Gynecol Scand. (1990); 69:197-207
  5. Cosmi E.V., Klimek R., Di Renzo G.C., Kulakov V., Kurjak A., Maeda K., Mandruzzato G.P., Van Gelin H.P., Wladimiroff J. (1997) Prognosis of birth term: recommendations on current practice and overview of new developments. Archiv. Perinat. Med., 3(2): 31-50.
  6. Cosmi E.V., Klimek R., et al. (FIGO Study Group Members) (1992) Recommendations on the use of ultrasound and Doppler technology in clinical obstetrics and gynecology. Int. J. Gynecol. Obstet., 37: 221-228.
  7. Cosmi E.V., Klimek R. (1993) Philosophy of birth: Natural process or artificial obstetrical procedure? Int. J. Gynecol. Obstet., 41: 231-232.
  8. Dubowitz L, Mercuri E, Dubowitz V.(1998) An optimality score for the neurologic examination of the term newborn. J Pediatr;133(3):406-416.
  9. Frączek A., Klimek R. (1998) Computer-aided monitoring of high-risk pregnancy. 1 Inter. Symp. “New Technologies in Reproductive Medicine, Neonatology and Gynecology”, Folgaria, Abstr.
  10. Hosemann H. Normale und abnorme Schwangerschaftsdauer. In Biologie und Pathologie des Weibes. Verlag Urban&Schwarzenberg, 1952,1.Teil,S.828-867,851-854,861.
  11. Klimek M.(1993) Psychological Aspects of Determining the Expected Date of Delivery. Int.J.and Perinatal Psychology and Medicine. 5, 2: 143-149.
  12. Klimek M.(1995) Psycho-medical prognosis versus mathematical prediction of birth term. Int.J.Prenatal and Perinatal Psychology and Medicine. 7, Supl. 1:39.
  13. Klimek M. (1994) Prognoza terminu porodu i stanu noworodka. Prognosis of birth-date and newborn state, DREAM Publishing Company, Inc., Cracow.
  14. Klimek M. (1995) A Critical Evaluation of Fetal Weight Assessment in Late Pregnancy. Int.J. Prenatal and Perinatal Psychology and Medicine, 7, 1: 17-22.
  15. Klimek M. (1995) Computer-Aided Ultrasonic Fetometry in Advanced Pregnancy. Int.J. Prenatal and Perinatal Psychology and Medicine, 7, 1: 7-16.
  16. Klimek M. (1995) Fetometria ultra-sô nica computadorizada na prenhez avanç ada. Ginecologia Obstetricia, GO, Junho, Sao Paulo, 4, 6: 85-92.
  17. Klimek M. (1995) Magnetic resonance imaging and ultrasonography in timing of pregnancy. In: E.V. Cosmi (ed) The Place for New Technologies in Gynecology, Obstetrics and Perinatology, Monduzzi Editore S.p.A.:145-150.
  18. Klimek M.(1995) Monitorowanie ciąży wspomagane komputerowo.(Computer-aided monitoring of pregnancy) In: Spaczyński M. (ed) Ultrasonografia w położnictwie i ginekologii. PZWL, Warsaw.
  19. Klimek M.(1996) Medical prognosis versus statistical prediction of birth term. In: Klimek R., Fedor-Freybergh P., Janus L., Walas-Skolicka E. (eds) A Time to Be Born. DREAM Publishing Company, Cracow: 9-33.
  20. Klimek M. (1996) Monitorowanie ciąży i prognozowanie porodu jako zdarzeń czasoprzestrzennych.(Monitoring of pregnancy and prognosis of birth as spacetime events). DREAM Publishing Comp. Inc., Cracow.
  21. Klimek M. (1997) La prognosi medica in rapporto alla predizione statistica del termine di gravidanza, in: Nascere, QUANDO?, G.C.Di Renzo, CIC Edizioni Internazionali, Roma: 15-37.
  22. Klimek M., Frączek A., Klimek R., Michalski A. (1993) Procedural errors of ultrasound dating of pregnancy using fetal dimensions. Congress of ESGOJ, Madonn a di Campiglio, Abs. FC68; Archivio Ostetrica e Ginecologia, 2: 35-38.
  23. Klimek R. (1967)Relative duration of human pregnancy and oxytocin therapy. Part I.. Gynecologia, 163: 48.
  24. Klimek R. (1967) Relative duration of human pregnancy and oxytocin therapy. Part II. Enzymic block. Gynecologia, 167: 54.
  25. Klimek R. (1991)Ultrasonography in terms of biological and calendar gestational age. Report F.I.G.O - Study Group on "Assessment of New Technology", DWN DReAM, Cracow.
  26. Klimek R. (1993) Iatrogenic consequences of inappropriate USG prediction of birth date. 3'd World Congress of Ultrasonography in OB/GYN, Las Vegas.
  27. Klimek R. (1993) Ultrasonographers contra Leonardo da Vinci. Quo vadis obstetric sonography? Int. J. Gynecol. Obstet., 3:114-117.
  28. Klimek R.(1994) Monitoring of pregnancy and prediction of birth-date. The Parthenon Publishing Group. London, New York.
  29. Klimek R. (1997) Birth-term: one day or five weeks. The Proceedings of 2nd World Congress on Labor and Delivery, Rome, R44; The Parthenon Publishing Group,: 45-49.
  30. Klimek R. (1997) Neue Einsichten in der Berechnung des Geburtstermins und ihre Konsequenzen fü r die medizinische Praxis. In: L.Janus, S.Haibach (eds) Seelisches erleben vor und wä hrend der Geburt, LinguaMed Verlags-GmbH, Neu-Isenburg: 103-111.
  31. Klimek R. (1998) Obstetrical interpretation of individual birth at term. J.Perinat.Med.,WAPM-Newssletter, 26: 69-72
  32. Klimek R. (1999) An authors’s personal responsibility for improper scales of obstetrical imaging. Med. Sci. Monit., 5 (1): 1-4.
  33. Klimek R.(2000) New obstetrical index of newborn maturity. (Prenatal and Neonatal Medicine, Abstracts of the XVI Inter.Congress The Fetus as a Patient, Fiuggi, Italy, 2000, 45) In: E.V.Cosmi (ed)The Fetus As A Patient, Monduzzi Editore S.p.A.: 61-65.
  34. Klimek R., Fedor-Freybergh P., Janus L., Walas-Skolicka E. (1996) A Time to Be Born. DREAM Publishing Company, Inc. Cracow.
  35. Klimek R., Fedor-Freybergh P., Janus L., Walas-Skolicka E. (1997) nascere, QUANDO?, CIC Edizioni Internazionali, Roma.
  36. Klimek R., Frączek A., Klimek M., Karolik A. (1998). Oxytocinase aided monitoring of fetal well being. Pre-Neonatal Medicine, 3, supll.: 168.
  37. Klimek R., Frączek A., Klimek M. (1998) Prognosis of birth term: new developments. 1 Inter. Symp. “New Technologies in Reproductive Medicine, Neonatology and Gynecology”, Folgaria, Abstr. R55; The Parthenon Publ.Group, New York-London, 1999: 107-110.
  38. Klimek R., Klimek M. (1992) Biological gestational age and its calendar assessment with ultrasound. Part 2: Biological-calendar scales for prediction of birth-date. Gynecol. Geburtsh. Rundsch., 32: 159-228.
  39. Klimek R., Klimek M., Rzepecka-Węglarz B. (2000) A new score for postnatal clinical assessment of fetal maturity in newborn infants. Int.J.Obst.Gyn., 71: 101-105.
  40. Klimek R., Król W. (ed.) (1964) "Oksytocyna i jej analogony. Oxytocin and its analogues”. Cracow Sympozjum Pol. Tow. Endokr.; Sprawozdanie, Gin.Pol., 2, 35: 290.
  41. Mazanek-Mościcka M., Klimek R. (2000) Aleksander Rosner ((1867-1930). w: J.Grochowski (red), Złota Księga Wydziału Lekarskiego Uniwersytetu Jagiellońskiego, Księgarnia Akademicka, Cracow: 333-338.
  42. Minakami H, Sato I. (1996) Reestimating date of delivery in multifetal pregnancies. JAMA May 8,275(18):1432-4.
  43. Report of the FIGO Sub-Committee on Perinatal Epidemiology and Health Statistics following a Workshop on the Methodology of Measurement and Recording of Infant Growth in the Perinatal Period. Dunn PM ed. Cairo November 11 to 18, 1984, International Federation of Gynecology and Obstetrics (FIGO), London,1986,Int J Gynaecol Obstet, 1986;24:486. Bull Int Pediatr Assoc, 1987;8:107
  44. Yerushalmy J. (1970) Relation of birth weight, gestational age, and the rate of intrauterine growth to peronatal mortality. Clin Obstet Gynecol.13(1):107-29